Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation

NK1, a splicing variant of hepatocyte growth factor (HGF), binds to and activates Met receptor by forming an NK1 dimer and 2:2 complex with Met. Although the structural mechanism underlying Met activation by HGF remains incompletely resolved, it has been proposed that the NK1 dimer structure partici...

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Detalles Bibliográficos
Autores principales: Tahira, Yumiko, Sakai, Katsuya, Sato, Hiroki, Imamura, Ryu, Matsumoto, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431453/
https://www.ncbi.nlm.nih.gov/pubmed/34502141
http://dx.doi.org/10.3390/ijms22179240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431453/
https://www.ncbi.nlm.nih.gov/pubmed/34502141
http://dx.doi.org/10.3390/ijms22179240

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