The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues

Previously, we showed that a nitric oxide synthase (NOS) inhibitor, compound T1023, induces transient hypoxia and prevents acute radiation syndrome (ARS) in mice. Significant efficacy (according to various tests, dose modifying factor (DMF)—1.6–1.9 against H-ARS/G-ARS) and safety in radioprotective...

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Detalles Bibliográficos
Autores principales: Filimonova, Marina, Saburova, Alina, Makarchuk, Victoria, Shevchenko, Ljudmila, Surinova, Valentina, Yuzhakov, Vadim, Yakovleva, Nina, Sevankaeva, Larisa, Saburov, Vyacheslav, Koryakin, Sergey, Shegay, Petr, Kaprin, Andrey, Ivanov, Sergey, Filimonov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431509/
https://www.ncbi.nlm.nih.gov/pubmed/34502247
http://dx.doi.org/10.3390/ijms22179340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431509/
https://www.ncbi.nlm.nih.gov/pubmed/34502247
http://dx.doi.org/10.3390/ijms22179340

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