Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

Romosozumab, a humanized monoclonal antibody specific for sclerostin (SOST), has been approved for treatment of postmenopausal women with osteoporosis at a high risk for fracture. Previous work in sclerostin global knockout (Sost(−/−)) mice indicated alterations in immune cell development in the bon...

Descripción completa

Detalles Bibliográficos
Autores principales: Donham, Cristine, Chicana, Betsabel, Robling, Alexander G., Mohamed, Asmaa, Elizaldi, Sonny, Chi, Michael, Freeman, Brian, Millan, Alberto, Murugesh, Deepa K., Hum, Nicholas R., Sebastian, Aimy, Loots, Gabriela G., Manilay, Jennifer O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431516/
https://www.ncbi.nlm.nih.gov/pubmed/34502021
http://dx.doi.org/10.3390/ijms22179111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431516/
https://www.ncbi.nlm.nih.gov/pubmed/34502021
http://dx.doi.org/10.3390/ijms22179111

Ejemplares similares