Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy

Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia associated with premature joint degeneration, is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that occur in articular chondrocytes of MT-COMP mice, a m...

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Detalles Bibliográficos
Autores principales: Hecht, Jacqueline T., Veerisetty, Alka C., Hossain, Mohammad G., Patra, Debabrata, Chiu, Frankie, Coustry, Francoise, Posey, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431545/
https://www.ncbi.nlm.nih.gov/pubmed/34502142
http://dx.doi.org/10.3390/ijms22179239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431545/
https://www.ncbi.nlm.nih.gov/pubmed/34502142
http://dx.doi.org/10.3390/ijms22179239

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