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Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy

Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia associated with premature joint degeneration, is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that occur in articular chondrocytes of MT-COMP mice, a m...

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Detalles Bibliográficos
Autores principales:	Hecht, Jacqueline T., Veerisetty, Alka C., Hossain, Mohammad G., Patra, Debabrata, Chiu, Frankie, Coustry, Francoise, Posey, Karen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431545/ https://www.ncbi.nlm.nih.gov/pubmed/34502142 http://dx.doi.org/10.3390/ijms22179239

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