Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model

Background: Sepsis is a serious, heterogeneous clinical entity produced by a severe and systemic host inflammatory response to infection. Methotrexate (MTX) is a folate-antagonist that induces the generation of adenosine and also inhibits JAK/STAT pathway; MTX it is widely used as an anti-inflammato...

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Detalles Bibliográficos
Autores principales: Bringué, Josep, Guillamat-Prats, Raquel, Martinez, Maria Luisa, Torrents, Eva, Camprubí-Rimblas, Marta, Blanch, Lluís, Artigas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431751/
https://www.ncbi.nlm.nih.gov/pubmed/34502521
http://dx.doi.org/10.3390/ijms22179612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431751/
https://www.ncbi.nlm.nih.gov/pubmed/34502521
http://dx.doi.org/10.3390/ijms22179612

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