In Silico Screening of Novel α1-GABA(A) Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines

The ionotropic GABA(A) receptor (GABA(A)R) has been proven to be an important target of atypical antipsychotics. A novel series of imidazo [1,2-a]-pyridine derivatives, as selective positive allosteric modulators (PAMs) of α1-containing GABA(A)Rs with potent antipsychotic activities, have been repor...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaojiao, Wang, Chenchen, Zhai, Na, Luo, Xiaogang, Liu, Genyan, Ju, Xiulian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431797/
https://www.ncbi.nlm.nih.gov/pubmed/34502550
http://dx.doi.org/10.3390/ijms22179645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431797/
https://www.ncbi.nlm.nih.gov/pubmed/34502550
http://dx.doi.org/10.3390/ijms22179645

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