Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation

SARS-CoV-2 nucleocapsid (N) protein undergoes RNA-induced phase separation (LLPS) and sequesters the host key stress granule (SG) proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and 2 (G3BP1 and G3BP2) to inhibit SG formation. This will allow viral packaging and propagation in h...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Nemat, Prasad, Kartikay, AlAsmari, Abdullah F., Alharbi, Metab, Rashid, Summya, Kumar, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431879/
https://www.ncbi.nlm.nih.gov/pubmed/34517025
http://dx.doi.org/10.1016/j.ijbiomac.2021.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431879/
https://www.ncbi.nlm.nih.gov/pubmed/34517025
http://dx.doi.org/10.1016/j.ijbiomac.2021.09.018

Ejemplares similares