Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) pathology at a young age, including amyloid plaques and neurofibrillary tangles (NFTs). Tau pathology can spread via extracellular vesicles, such as exosomes. The cargo of neuron-derived small extracellular vesicles (NDEVs) from in...

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Detalles Bibliográficos
Autores principales: Ledreux, Aurélie, Thomas, Sarah, Hamlett, Eric D., Trautman, Camille, Gilmore, Anah, Rickman Hager, Emily, Paredes, Daniel A., Margittai, Martin, Fortea, Juan, Granholm, Ann-Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432237/
https://www.ncbi.nlm.nih.gov/pubmed/34501378
http://dx.doi.org/10.3390/jcm10173931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432237/
https://www.ncbi.nlm.nih.gov/pubmed/34501378
http://dx.doi.org/10.3390/jcm10173931

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