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Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) pathology at a young age, including amyloid plaques and neurofibrillary tangles (NFTs). Tau pathology can spread via extracellular vesicles, such as exosomes. The cargo of neuron-derived small extracellular vesicles (NDEVs) from in...

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Detalles Bibliográficos
Autores principales:	Ledreux, Aurélie, Thomas, Sarah, Hamlett, Eric D., Trautman, Camille, Gilmore, Anah, Rickman Hager, Emily, Paredes, Daniel A., Margittai, Martin, Fortea, Juan, Granholm, Ann-Charlotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432237/ https://www.ncbi.nlm.nih.gov/pubmed/34501378 http://dx.doi.org/10.3390/jcm10173931

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