Cargando…

Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy

Genes in the epoxygenase pathway of arachidonic acid metabolism leading to vasoactive eicosanoids, mainly 20-hydroxyeicosatetraenoic (20-HETE) and epoxyeicosatrienoic (EETs) acids, have been related to glucose-induced renal damage in preclinical reports. We genotyped 1088 diabetic kidney disease (DK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mota-Zamorano, Sonia, Robles, Nicolás R., González, Luz M., Valdivielso, José M., Lopez-Gomez, Juan, Cancho, Bárbara, García-Pino, Guadalupe, Gervasini, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432556/ https://www.ncbi.nlm.nih.gov/pubmed/34501433 http://dx.doi.org/10.3390/jcm10173980

Ejemplares similares

Plasma and urinary concentrations of arachidonic acid-derived eicosanoids are associated with diabetic kidney disease
por: Mota-Zamorano, Sonia, et al.
Publicado: (2021)

A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease
por: Mota-Zamorano, Sonia, et al.
Publicado: (2021)

Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy
por: Mota-Zamorano, Sonia, et al.
Publicado: (2022)

Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients
por: González, Luz María, et al.
Publicado: (2021)

Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation
por: Mota-Zamorano, Sonia, et al.
Publicado: (2019)

Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients
por: González, Luz M., et al.
Publicado: (2023)

Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk
por: González, Luz M., et al.
Publicado: (2022)

Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation
por: Mota-Zamorano, Sonia, et al.
Publicado: (2020)

Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage
por: Li, Jing, et al.
Publicado: (2014)

Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells
por: Shao, Jing, et al.
Publicado: (2016)

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease
por: Gervasini, Guillermo, et al.
Publicado: (2023)

Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways
por: Wei, Yuan, et al.
Publicado: (2004)

Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders
por: Yui, Kunio, et al.
Publicado: (2015)

Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study
por: Chistyakov, Dmitry V., et al.
Publicado: (2018)

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity
por: Bystrom, Jonas, et al.
Publicado: (2011)

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
por: Koundouros, Nikos, et al.
Publicado: (2020)

The Emerging Role of the Double-Edged Impact of Arachidonic Acid-Derived Eicosanoids in the Neuroinflammatory Background of Depression
por: Regulska, Magdalena, et al.
Publicado: (2021)

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells
por: Askari, Ara A., et al.
Publicado: (2014)

The effect of antibiotic exposure on eicosanoid generation from arachidonic acid and gene expression in a primitive chordate, Branchiostoma belcheri
por: Yuan, Dongjuan, et al.
Publicado: (2015)

Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity
por: Monk, Jennifer M., et al.
Publicado: (2014)

Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators
por: Ouldamer, Lobna, et al.
Publicado: (2022)

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis
por: Sharma, Amit, et al.
Publicado: (2016)

A Novel Role for Cytochrome P450 Epoxygenase Metabolites in Septic Shock
por: Jones, Timothy N., et al.
Publicado: (2022)

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators
por: Shi, Zeqi, et al.
Publicado: (2022)

Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling
por: Conroy, Jennie L., et al.
Publicado: (2010)

Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo
por: Rao, T. S., et al.
Publicado: (1993)

The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension
por: McNeill, Jenna N., et al.
Publicado: (2023)

The Cytochrome P450 Epoxygenase Pathway Regulates the Hepatic Inflammatory Response in Fatty Liver Disease
por: Schuck, Robert N., et al.
Publicado: (2014)

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers
por: Pidkovka, Nataliya, et al.
Publicado: (2021)

Eicosanoids in reproduction /
Publicado: (1990)

Eicosanoids and cancer
por: Gomes, Renata Nascimento, et al.
Publicado: (2018)

INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage
por: Leitner, Gerda C., et al.
Publicado: (2022)

Editorial: Eicosanoids in Cancer
por: Markosyan, Nune, et al.
Publicado: (2021)

The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
por: Wray, Jessica A., et al.
Publicado: (2009)

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis
por: Olona, Antoni, et al.
Publicado: (2018)

High dietary arachidonic acid levels induce changes in complex lipids and immune-related eicosanoids and increase levels of oxidised metabolites in zebrafish (Danio rerio)
por: Adam, Anne-Catrin, et al.
Publicado: (2017)

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis
por: Gong, Yan, et al.
Publicado: (2016)

Regulation of eicosanoid synthesis by leptin
por: Mancuso, P, et al.
Publicado: (2004)

Arachidonic Acid Cascade and Eicosanoid Production Are Elevated While LTC4 Synthase Modulates the Lipidomics Profile in the Brain of the HIVgp120-Transgenic Mouse Model of NeuroHIV
por: Yuan, Nina Y., et al.
Publicado: (2022)

Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population
por: Tantray, Javeed Ahmad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_459651nh8i0rj9drbl7r6dm540