Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy

To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide (the chromodomain of the CBX1 protein) was fused...

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Detalles Bibliográficos
Autores principales: Van Looveren, Dominique, Giacomazzi, Giorgia, Thiry, Irina, Sampaolesi, Maurilio, Gijsbers, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433069/
https://www.ncbi.nlm.nih.gov/pubmed/34553002
http://dx.doi.org/10.1016/j.omtm.2021.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433069/
https://www.ncbi.nlm.nih.gov/pubmed/34553002
http://dx.doi.org/10.1016/j.omtm.2021.07.003

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