Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo

Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies. To exploit the synthetic lethality concept in the design of chemical anti-cancer agents, we developed a bio-orthogonally catalyzed lethality (BCL) strategy to generat...

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Detalles Bibliográficos
Autores principales: Xue, Xuling, Qian, Chenggen, Tao, Qin, Dai, Yuanxin, Lv, Mengdi, Dong, Jingwen, Su, Zhi, Qian, Yong, Zhao, Jing, Liu, Hong-Ke, Guo, Zijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433091/
https://www.ncbi.nlm.nih.gov/pubmed/34691728
http://dx.doi.org/10.1093/nsr/nwaa286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433091/
https://www.ncbi.nlm.nih.gov/pubmed/34691728
http://dx.doi.org/10.1093/nsr/nwaa286

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