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Interpreting a black box predictor to gain insights into early folding mechanisms

Protein folding and function are closely connected, but the exact mechanisms by which proteins fold remain elusive. Early folding residues (EFRs) are amino acids within a particular protein that induce the very first stages of the folding process. High-resolution EFR data are only available for few...

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Detalles Bibliográficos
Autores principales: Grau, Isel, Nowé, Ann, Vranken, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433119/
https://www.ncbi.nlm.nih.gov/pubmed/34527196
http://dx.doi.org/10.1016/j.csbj.2021.08.041