Striatal ΔFosB gene suppression inhibits the development of abnormal involuntary movements induced by L-Dopa in rats

L-Dopa-induced dyskinesia (LID) is associated with upregulation of striatal ΔFosB in animal models and patients with Parkinson’s disease (PD). A mechanistic role of ΔFosB is suspected because its transgenic overexpression leads to early appearance of LID in rodents and primates. The present study in...

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Detalles Bibliográficos
Autores principales: Beck, Goichi, Zhang, Jie, Fong, Kayoko, Mochizuki, Hideki, Mouradian, M. Maral, Papa, Stella M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433270/
https://www.ncbi.nlm.nih.gov/pubmed/33707771
http://dx.doi.org/10.1038/s41434-021-00249-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433270/
https://www.ncbi.nlm.nih.gov/pubmed/33707771
http://dx.doi.org/10.1038/s41434-021-00249-7

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