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Single-cell lactate production rate as a measure of glycolysis in endothelial cells
Heterogeneous metabolism supports critical single-cell functions. Here, we describe deep-learning-enabled image analyses of a genetically encoded lactate-sensing probe which can accurately quantify metabolite levels and glycolytic rates at the single-cell level. Multiple strategies and test data hav...
Autores principales: | Harrison, Devin, Wu, David, Huang, Jun, Fang, Yun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433287/ https://www.ncbi.nlm.nih.gov/pubmed/34527962 http://dx.doi.org/10.1016/j.xpro.2021.100807 |
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