Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are unclear. Here, we show that preformed α-syn fibrils (PFF) increase the association between TLR2 and MyD88, resulti...

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Detalles Bibliográficos
Autores principales: Dutta, Debashis, Jana, Malabendu, Majumder, Moumita, Mondal, Susanta, Roy, Avik, Pahan, Kalipada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433339/
https://www.ncbi.nlm.nih.gov/pubmed/34508096
http://dx.doi.org/10.1038/s41467-021-25767-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433339/
https://www.ncbi.nlm.nih.gov/pubmed/34508096
http://dx.doi.org/10.1038/s41467-021-25767-1

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