Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

Bivalent ligands are composed of two pharmacophores connected by a spacer of variable size. These ligands are able to simultaneously recognize two binding sites, for example in a G protein-coupled receptor heterodimer, resulting in enhanced binding affinity. Taking advantage of previously described...

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Detalles Bibliográficos
Autores principales: Budzinski, Julian, Maschauer, Simone, Kobayashi, Hiroyuki, Couvineau, Pierre, Vogt, Hannah, Gmeiner, Peter, Roggenhofer, Anna, Prante, Olaf, Bouvier, Michel, Weikert, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433439/
https://www.ncbi.nlm.nih.gov/pubmed/34508168
http://dx.doi.org/10.1038/s42003-021-02574-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433439/
https://www.ncbi.nlm.nih.gov/pubmed/34508168
http://dx.doi.org/10.1038/s42003-021-02574-4

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