Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice

Patterned degeneration of Purkinje cells (PCs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. Sphingolipid metabolism dyshomeostasis typically leads to PC neurodegeneration; hence, we questioned whether local sphingol...

Descripción completa

Detalles Bibliográficos
Autores principales: Blot, François G. C., Krijnen, Wilhelmina H. J. J., Den Hoedt, Sandra, Osório, Catarina, White, Joshua J., Mulder, Monique T., Schonewille, Martijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433568/
https://www.ncbi.nlm.nih.gov/pubmed/34479994
http://dx.doi.org/10.1073/pnas.2016969118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433568/
https://www.ncbi.nlm.nih.gov/pubmed/34479994
http://dx.doi.org/10.1073/pnas.2016969118

Ejemplares similares