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Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice

Patterned degeneration of Purkinje cells (PCs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. Sphingolipid metabolism dyshomeostasis typically leads to PC neurodegeneration; hence, we questioned whether local sphingol...

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Detalles Bibliográficos
Autores principales:	Blot, François G. C., Krijnen, Wilhelmina H. J. J., Den Hoedt, Sandra, Osório, Catarina, White, Joshua J., Mulder, Monique T., Schonewille, Martijn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433568/ https://www.ncbi.nlm.nih.gov/pubmed/34479994 http://dx.doi.org/10.1073/pnas.2016969118

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