Sensitization to Drug Treatment in Precursor B-Cell Acute Lymphoblastic Leukemia Is Not Achieved by Stromal NF-κB Inhibition of Cell Adhesion but by Stromal PKC-Dependent Inhibition of ABC Transporters Activity

Cell adhesion to stromal support and the associated intracellular signaling are central to drug resistance, therefore blocking both has been effective in increasing drug sensitization in leukemia. The stromal Ser/Thr protein kinase C (PKC) has been found to be important for conferring protection to...

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Detalles Bibliográficos
Autores principales: Ruiz-Aparicio, Paola Fernanda, Uribe, Gloria Inés, Linares-Ballesteros, Adriana, Vernot, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433757/
https://www.ncbi.nlm.nih.gov/pubmed/34500796
http://dx.doi.org/10.3390/molecules26175366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433757/
https://www.ncbi.nlm.nih.gov/pubmed/34500796
http://dx.doi.org/10.3390/molecules26175366

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