Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening

Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2. Compound 15l showed the most inhibitory activities among th...

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Detalles Bibliográficos
Autores principales: Elkamhawy, Ahmed, Ammar, Usama M., Paik, Sora, Abdellattif, Magda H., Elsherbeny, Mohamed H., Lee, Kyeong, Roh, Eun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433807/
https://www.ncbi.nlm.nih.gov/pubmed/34500757
http://dx.doi.org/10.3390/molecules26175324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433807/
https://www.ncbi.nlm.nih.gov/pubmed/34500757
http://dx.doi.org/10.3390/molecules26175324

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