ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P(1) Agonist and Functional Antagonist Potency In Vitro and In Vivo

Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P(1) internalization upon S1P binding and recycling to the cell surface when local S1P...

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Detalles Bibliográficos
Autores principales: Stepanovska Tanturovska, Bisera, Zivkovic, Aleksandra, Imeri, Faik, Homann, Thomas, Kleuser, Burkhard, Stark, Holger, Huwiler, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433829/
https://www.ncbi.nlm.nih.gov/pubmed/34500564
http://dx.doi.org/10.3390/molecules26175134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433829/
https://www.ncbi.nlm.nih.gov/pubmed/34500564
http://dx.doi.org/10.3390/molecules26175134

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