Cargando…

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P(1) Agonist and Functional Antagonist Potency In Vitro and In Vivo

Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P(1) internalization upon S1P binding and recycling to the cell surface when local S1P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stepanovska Tanturovska, Bisera, Zivkovic, Aleksandra, Imeri, Faik, Homann, Thomas, Kleuser, Burkhard, Stark, Holger, Huwiler, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433829/ https://www.ncbi.nlm.nih.gov/pubmed/34500564 http://dx.doi.org/10.3390/molecules26175134

Ejemplares similares

Morpholino Analogues of Fingolimod as Novel and Selective S1P(1) Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis
por: Stepanovska, Bisera, et al.
Publicado: (2020)

Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation
por: Imeri, Faik, et al.
Publicado: (2023)

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
por: Hafizi, Redona, et al.
Publicado: (2022)

Lipids as Targets for Renal Cell Carcinoma Therapy
por: Stepanovska Tanturovska, Bisera, et al.
Publicado: (2023)

Dominique Anel and the small lachrymal syringe.
por: Price, J
Publicado: (1969)

S1P Stimulates Erythropoietin Production in Mouse Renal Interstitial Fibroblasts by S1P(1) and S1P(3) Receptor Activation and HIF-2α Stabilization
por: Hafizi, Redona, et al.
Publicado: (2021)

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge
por: Stepanovska, Bisera, et al.
Publicado: (2020)

The influence of SYRIZA-ANEL Greek health policies on hospital efficiency
por: Farantos, Georgios I., et al.
Publicado: (2023)

2191: The SDM learning loop model
por: Ronis, Sarah, et al.
Publicado: (2018)

Calcificação Caseosa do Anel Mitral: Diagnóstico Pós-Transplante Cardíaco
por: Chaves, Bruno Jordão, et al.
Publicado: (2022)

Volumosa Calcificação Caseosa do Anel Mitral em Localização Atípica
por: Correia, Joana Laranjeira, et al.
Publicado: (2022)

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells
por: Blanchard, Olivier, et al.
Publicado: (2018)

MD2191 – β∗–Reach: 2017 IR7 Collimation Hierarchy Limit and Impedance
por: Mereghetti, Alessio, et al.
Publicado: (2021)

2191. Hepatitis A Outbreak in Southeast Michigan: No Longer a Third World Disease
por: Altamimi, Sarah, et al.
Publicado: (2018)

The Effect of Silver Nanoparticles on Listeria monocytogenes PCM2191 Peptidoglycan Metabolism and Cell Permeability
por: MARKOWSKA, KATARZYNA, et al.
Publicado: (2018)

Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells
por: Gerecke, Christian, et al.
Publicado: (2019)

Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191
por: Sanduja, Pooja, et al.
Publicado: (2020)

2191. An Assessment of Penicillin Allergy Documentation among Patients undergoing Elective Surgeries and Ambulatory Procedures
por: Banach, David, et al.
Publicado: (2023)

Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease
por: Voelter-Mahlknecht, Susanne, et al.
Publicado: (2012)

Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice
por: Pawlik, Agata, et al.
Publicado: (2020)

Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease
por: Kleuser, Burkhard
Publicado: (2018)

PB2191: A RETROSPECTIVE MULTI-CENTER STUDY ON DIRECT ORAL ANTICOAGULANT USE IN BCR::ABL1 NEGATIVE MYELOPROLIFERATIVE NEOPLASMS
por: Baysal, Mehmet, et al.
Publicado: (2023)

The Role of Ten-Eleven Translocation Proteins in Inflammation
por: Gerecke, Christian, et al.
Publicado: (2022)

PReS-FINAL-2191: Imaging of chronic recurrent multifocal osteitis: a french national cohort of 178 cases
por: Wipff, J, et al.
Publicado: (2013)

Cloning and characterization of MAP2191 gene, a mammalian cell entry antigen of Mycobacterium avium subspecies paratuberculosis
por: Hemati, Zahra, et al.
Publicado: (2018)

Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
por: Filip-Psurska, Beata, et al.
Publicado: (2021)

Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases
por: Kleuser, Burkhard, et al.
Publicado: (2023)

Determination of Seminal Concentration of Fingolimod and Fingolimod‐Phosphate in Multiple Sclerosis Patients Receiving Chronic Treatment With Fingolimod
por: David, Olivier J., et al.
Publicado: (2017)

In silico Docking Studies of Fingolimod and S1P(1) Agonists
por: Marciniak, Alexander, et al.
Publicado: (2020)

2191. The Sputum FilmArray Pneumonia Panel (SFAPP) Outperforms a Diagnostic Bundle in Patients with Community-Acquired Pneumonia (CAP)
por: Gilbert, David N, et al.
Publicado: (2019)

Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis
por: Japtok, Lukasz, et al.
Publicado: (2014)

Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191
por: Maj, Ewa, et al.
Publicado: (2021)

Abstract No.: ABS2191 : Comparative study between perfusion index and sensory function tests for determination of successful supraclavicular brachial plexus block
por: Joshi, Priyanka
Publicado: (2022)

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection [published erratum appears in J Exp Med 1989 Dec 1;170(6):2191]
Publicado: (1989)

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells
por: Gerecke, Christian, et al.
Publicado: (2018)

Fingolimod inhibits multiple stages of the HIV-1 life cycle
por: Resop, Rachel S., et al.
Publicado: (2020)

The Enigma of Sphingolipids in Health and Disease
por: Kleuser, Burkhard
Publicado: (2018)

Antidepressant activity of fingolimod in mice
por: di Nuzzo, Luigi, et al.
Publicado: (2015)

Fingolimod for Irradiation-Induced Neurodegeneration
por: Metzdorf, Judith, et al.
Publicado: (2019)

PB2191: CENTRAL VENOUS ACCESS AND PERIPHERALLY INSERTED CENTRAL CATHETERS IN HEMATOPOIETIC STEM CELL TRANSPLANTATION: A RETROSPECTIVE COMPARISON OF POSSIBLE COMPLICATION RATES
por: Mele, A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rpl47lgh5q5p9oqdkqure18bpu