First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer’s disease (AD). Aiming at discovering novel multimodal agents addressing thr and AD-related targets, a selection of previously and newly synthesized potent thr and factor Xa (fXa) inhib...

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Detalles Bibliográficos
Autores principales: Purgatorio, Rosa, Gambacorta, Nicola, de Candia, Modesto, Catto, Marco, Rullo, Mariagrazia, Pisani, Leonardo, Nicolotti, Orazio, Altomare, Cosimo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434007/
https://www.ncbi.nlm.nih.gov/pubmed/34500640
http://dx.doi.org/10.3390/molecules26175208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434007/
https://www.ncbi.nlm.nih.gov/pubmed/34500640
http://dx.doi.org/10.3390/molecules26175208

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