When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?

Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus). CdPus may become a component of clustered DNA lesions (CDL), which are notably unfavorable for the base excision repair...

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Detalles Bibliográficos
Autores principales: Szewczuk, Michał, Boguszewska, Karolina, Kaźmierczak-Barańska, Julia, Karwowski, Bolesław T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434022/
https://www.ncbi.nlm.nih.gov/pubmed/34500606
http://dx.doi.org/10.3390/molecules26175177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434022/
https://www.ncbi.nlm.nih.gov/pubmed/34500606
http://dx.doi.org/10.3390/molecules26175177

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