Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-d]pyrimidines. The series synthesized offers a chemical diversity in C-7 whereas C-2 (3-hydroxyphenyl) and C-4 groups (morpholine) r...

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Detalles Bibliográficos
Autores principales: Buron, Frédéric, Rodrigues, Nuno, Saurat, Thibault, Hiebel, Marie Aude, Bourg, Stéphane, Bonnet, Pascal, Nehmé, Reine, Morin, Philippe, Percina, Nathalie, Corret, Justine, Vallée, Béatrice, le Guevel, Remy, Jourdan, Marie-Lise, Bénédetti, Hélène, Routier, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434050/
https://www.ncbi.nlm.nih.gov/pubmed/34500781
http://dx.doi.org/10.3390/molecules26175349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434050/
https://www.ncbi.nlm.nih.gov/pubmed/34500781
http://dx.doi.org/10.3390/molecules26175349

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