New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway

Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by spectroscopic techniques and elemental analysis. Furthermore, all compounds were investigated in silico for their ability to...

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Detalles Bibliográficos
Autores principales: Noser, Ahmed A., Abdelmonsef, Aboubakr H., El-Naggar, Mohamed, Salem, Maha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434356/
https://www.ncbi.nlm.nih.gov/pubmed/34500765
http://dx.doi.org/10.3390/molecules26175332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434356/
https://www.ncbi.nlm.nih.gov/pubmed/34500765
http://dx.doi.org/10.3390/molecules26175332

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