Cargando…

Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions

DNA methyltransferases (DNMTs) including DNMT1 are a conserved family of cytosine methylases that play crucial roles in epigenetic regulation. The versatile functions of DNMT1 rely on allosteric networks between its different interacting partners, emerging as novel therapeutic targets. In this work,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Yu, Ye, Fei, Zhou, Ziyun, Liu, Wanlin, Liang, Zhongjie, Hu, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434485/ https://www.ncbi.nlm.nih.gov/pubmed/34500587 http://dx.doi.org/10.3390/molecules26175153

Ejemplares similares

HIV-1 Envelope Conformation, Allostery, and Dynamics
por: Bennett, Ashley Lauren, et al.
Publicado: (2021)

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
por: Dove, Katja K., et al.
Publicado: (2017)

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency
por: Manczyk, Noah, et al.
Publicado: (2019)

Conformational gating, dynamics and allostery in human monoacylglycerol lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2020)

Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s
por: Liang, Zhongjie, et al.
Publicado: (2020)

Independent functions of DNMT1 and USP7 at replication foci
por: Yarychkivska, Olya, et al.
Publicado: (2018)

A Ubiquitin Shuttle DC-UbP/UBTD2 Reconciles Protein Ubiquitination and Deubiquitination via Linking UbE1 and USP5 Enzymes
por: Song, Ai-Xin, et al.
Publicado: (2014)

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response
por: Wang, Zhiquan, et al.
Publicado: (2016)

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
por: Cheng, Jingdong, et al.
Publicado: (2015)

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM
por: Zhang, Shuwen, et al.
Publicado: (2022)

The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor
por: Shi, Yuxin, et al.
Publicado: (2022)

New open conformation of SMYD3 implicates conformational selection and allostery
por: Spellmon, Nicholas, et al.
Publicado: (2016)

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
por: Felle, Max, et al.
Publicado: (2011)

The USP21 Short Variant (USP21SV) Lacking NES, Located Mostly in the Nucleus In Vivo, Activates Transcription by Deubiquitylating ubH2A In Vitro
por: Okuda, Hiroshi, et al.
Publicado: (2013)

Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
por: Peiffer, Amanda L., et al.
Publicado: (2022)

Phenol sensing in nature is modulated via a conformational switch governed by dynamic allostery
por: Singh, Jayanti, et al.
Publicado: (2022)

Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles
por: Fenwick, R. Bryn, et al.
Publicado: (2011)

USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment
por: Li, Jialun, et al.
Publicado: (2020)

NMR Methods to Study Dynamic Allostery
por: Grutsch, Sarina, et al.
Publicado: (2016)

Dynamic allostery in thrombin—a review
por: Komives, Elizabeth A.
Publicado: (2023)

Ligand-specific conformational change drives interdomain allostery in Pin1
por: Born, Alexandra, et al.
Publicado: (2022)

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
por: Wang, Xudong, et al.
Publicado: (2023)

Insights into the molecular mechanism of allostery in Hsp70s
por: Mayer, Matthias P., et al.
Publicado: (2015)

Editorial: Understanding Protein Dynamics, Binding and Allostery for Drug Design
por: Hu, Guang, et al.
Publicado: (2021)

USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
por: Sijm, Ayestha, et al.
Publicado: (2022)

Dynamic Allostery in the Methionine Repressor Revealed by Force Distribution Analysis
por: Stacklies, Wolfram, et al.
Publicado: (2009)

Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration
por: Jantrapirom, Salinee, et al.
Publicado: (2019)

Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases
por: Novinec, Marko
Publicado: (2017)

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation
por: Condos, Tara EC, et al.
Publicado: (2018)

Protective Effects of Sesamin on Cytoxan-Induced Spermatogenesis Dysfunction by Regulating RNF8-ubH2A/ubH2B Pathways in Male Mice
por: Hai, Dong-Mei, et al.
Publicado: (2021)

Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension
por: Nakasone, Mark A., et al.
Publicado: (2022)

Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin‐1
por: Bertuzzi, Sara, et al.
Publicado: (2020)

Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor
por: Glasgow, Anum, et al.
Publicado: (2023)

Synergistic Allostery in Multiligand-Protein Interactions
por: Ghode, Abhijeet, et al.
Publicado: (2020)

Crystal structure of unliganded TRAP: implications for dynamic allostery
por: Malay, Ali D., et al.
Publicado: (2011)

Dynamic allostery can drive cold adaptation in enzymes
por: Saavedra, Harry G., et al.
Publicado: (2018)

Editorial: Structural and Dynamic Aspects of Protein Function and Allostery
por: Lisi, George P., et al.
Publicado: (2022)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
por: Adhikary, Santanu, et al.
Publicado: (2019)

Deubiquitination of FBP1 by USP7 blocks FBP1–DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors
por: Cheng, Xiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2nkkuumeoim04qo6rigq0827eh