Cargando…

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

PURPOSE: Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide with elevated intraocular pressure (IOP) as the most important risk factor. POAG IOP elevation is due to pathological changes in the trabecular meshwork (TM). Elevated TGFβ2 contributes to these changes and increas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rayana, Naga Pradeep, Sugali, Chenna Kesavulu, Dai, Jiannong, Peng, Michael, Liu, Shaohui, Zhang, Yucheng, Wan, Jun, Mao, Weiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2021
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434756/ https://www.ncbi.nlm.nih.gov/pubmed/34499703 http://dx.doi.org/10.1167/iovs.62.12.7

Ejemplares similares

The Role of the Ocular Tissue in SARS-CoV-2 Transmission
por: Peng, Michael, et al.
Publicado: (2020)

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma
por: Patel, Gaurang C., et al.
Publicado: (2019)

Comparison of Lamina Cribrosa Morphology in Eyes with Ocular Hypertension and Normal-Tension Glaucoma
por: Kim, Ji-Ah, et al.
Publicado: (2020)

HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
por: Bermudez, Jaclyn Y., et al.
Publicado: (2016)

Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients
por: Gustavsson, Simon T., et al.
Publicado: (2023)

The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma
por: Sayah, Diane N., et al.
Publicado: (2020)

ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice
por: Mody, Avani A., et al.
Publicado: (2021)

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia
por: Hong, Kyung Euy, et al.
Publicado: (2022)

Dynamic Scheimpflug Ocular Biomechanical Parameters in Untreated Primary Open Angle Glaucoma Eyes
por: Miki, Atsuya, et al.
Publicado: (2020)

Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model
por: Nettesheim, April, et al.
Publicado: (2020)

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10
por: Wu, Hang-Jing, et al.
Publicado: (2021)

Racial and Ethnic Differences in the Roles of Myopia and Ocular Biometrics as Risk Factors for Primary Open-Angle Glaucoma
por: Zhou, Sarah, et al.
Publicado: (2023)

Evidence of Hypoxic Glial Cells in a Model of Ocular Hypertension
por: Jassim, Assraa H., et al.
Publicado: (2019)

Heterozygous Pitx2 Null Mice Accurately Recapitulate the Ocular Features of Axenfeld-Rieger Syndrome and Congenital Glaucoma
por: Chen, Lisheng, et al.
Publicado: (2016)

DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway
por: Yoshida, Masaaki, et al.
Publicado: (2023)

Vision Parameters Most Important to Functionality in Glaucoma
por: Shakarchi, Ahmed F., et al.
Publicado: (2019)

Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma
por: Oikawa, Kazuya, et al.
Publicado: (2023)

Gait and Balance as Predictors and/or Mediators of Falls in Glaucoma
por: Mihailovic, Aleksandra, et al.
Publicado: (2020)

Impact of the Ability to Divide Attention on Reading Performance in Glaucoma
por: Swenor, Bonnielin K., et al.
Publicado: (2017)

Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma
por: Odden, Jamie L., et al.
Publicado: (2016)

Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins
por: Zhang, Liwei, et al.
Publicado: (2017)

The Molecular Processes in the Trabecular Meshwork After Exposure to Corticosteroids and in Corticosteroid-Induced Ocular Hypertension
por: Liesenborghs, Ilona, et al.
Publicado: (2020)

TGFβ2 Induces the Formation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells Through the Smad and Non-Smad Dependent Pathways
por: Montecchi-Palmer, Michela, et al.
Publicado: (2017)

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models
por: Roy Chowdhury, Uttio, et al.
Publicado: (2022)

Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension
por: Zhang, Chengshou, et al.
Publicado: (2023)

Inhibitory Effects of 3′,4′-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts
por: Fan Gaskin, Jennifer C., et al.
Publicado: (2022)

Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma
por: Amato, Rosario, et al.
Publicado: (2023)

Assessing Functional Disability in Glaucoma: The Relative Importance of Central Versus Far Peripheral Visual Fields
por: Odden, Jamie L., et al.
Publicado: (2020)

Difference in glaucoma progression between the first and second eye after consecutive bilateral glaucoma surgery in patients with bilateral uveitic glaucoma
por: Din, Norshamsiah Md, et al.
Publicado: (2016)

Long-Term Protection of Retinal Ganglion Cells and Visual Function by Brain-Derived Neurotrophic Factor in Mice With Ocular Hypertension
por: Feng, Liang, et al.
Publicado: (2016)

The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model
por: Deng, Chaohua, et al.
Publicado: (2020)

Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner/Outer Retinal Plexiform Layers
por: Noailles, Agustina, et al.
Publicado: (2022)

Visual Crowding in Glaucoma
por: Ogata, Nara G., et al.
Publicado: (2019)

Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature
por: Ramdas, Wishal D., et al.
Publicado: (2018)

The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model
por: Fazio, Massimo A., et al.
Publicado: (2019)

Estimation of the Disc Damage Likelihood Scale in primary open-angle glaucoma: the Glaucoma Stereo Analysis Study
por: Kitaoka, Yasushi, et al.
Publicado: (2015)

Efficient capture of high-quality real-world data on treatments for glaucoma: the Fight Glaucoma Blindness! Registry
por: Lawlor, Mitchell, et al.
Publicado: (2021)

XEN® implantation: an effective strategy to stop glaucoma progression despite prior minimally invasive glaucoma surgery
por: Davids, Anja-Maria, et al.
Publicado: (2022)

Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma
por: Pradhan, Zia S., et al.
Publicado: (2019)

Macula Vessel Density and Foveal Avascular Zone Parameters in Exfoliation Glaucoma Compared to Primary Open-Angle Glaucoma
por: Philip, Shawn, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_58ui95eevgv3hh3komkcqqa6st