NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells

Sustained activation of the Ca(2+)-release-activated Ca(2+) (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the pore subunit of CRAC channels, is limited in effector T...

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Detalles Bibliográficos
Autores principales: Wu, Beibei, Woo, Jin Seok, Vila, Pamela, Jew, Marcus, Leung, Jennifer, Sun, Zuoming, Srikanth, Sonal, Gwack, Yousang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435239/
https://www.ncbi.nlm.nih.gov/pubmed/34433025
http://dx.doi.org/10.1016/j.celrep.2021.109603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435239/
https://www.ncbi.nlm.nih.gov/pubmed/34433025
http://dx.doi.org/10.1016/j.celrep.2021.109603

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