Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease

BACKGROUND: Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed that cystic cholangiocytes are characterized by endoplasmic reticulum stress a...

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Detalles Bibliográficos
Autores principales: Lee‐Law, Pui Y., Olaizola, Paula, Caballero‐Camino, Francisco J., Izquierdo‐Sanchez, Laura, Rodrigues, Pedro M., Perugorria, Maria J., Azkargorta, Mikel, Elortza, Felix, Martinez‐Chantar, Maria L., Aspichueta, Patricia, Marzioni, Marco, Bujanda, Luis, Drenth, Joost P. H., Banales, Jesus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Hepatobiliary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435261/
https://www.ncbi.nlm.nih.gov/pubmed/34310849
http://dx.doi.org/10.1002/ueg2.12126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435261/
https://www.ncbi.nlm.nih.gov/pubmed/34310849
http://dx.doi.org/10.1002/ueg2.12126

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