Cargando…

Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease

BACKGROUND: Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed that cystic cholangiocytes are characterized by endoplasmic reticulum stress a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee‐Law, Pui Y., Olaizola, Paula, Caballero‐Camino, Francisco J., Izquierdo‐Sanchez, Laura, Rodrigues, Pedro M., Perugorria, Maria J., Azkargorta, Mikel, Elortza, Felix, Martinez‐Chantar, Maria L., Aspichueta, Patricia, Marzioni, Marco, Bujanda, Luis, Drenth, Joost P. H., Banales, Jesus M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Hepatobiliary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435261/ https://www.ncbi.nlm.nih.gov/pubmed/34310849 http://dx.doi.org/10.1002/ueg2.12126

Ejemplares similares

Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
por: Lee-Law, Pui Y., et al.
Publicado: (2020)

Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
por: Caballero‐Camino, Francisco J., et al.
Publicado: (2020)

Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease
por: Temmerman, Frederik, et al.
Publicado: (2017)

Extracellular Vesicles in Hepatobiliary Malignancies
por: Lapitz, Ainhoa, et al.
Publicado: (2018)

Virtual monoenergetic images from spectral detector computed tomography facilitate washout assessment in arterially hyper-enhancing liver lesions
por: Reimer, R. P., et al.
Publicado: (2020)

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients
por: Serrano-Maciá, Marina, et al.
Publicado: (2022)

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
por: Serrano-Maciá, Marina, et al.
Publicado: (2021)

Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise
por: Saha, Supriya K., et al.
Publicado: (2016)

Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma
por: Sanoff, Hanna K., et al.
Publicado: (2016)

Next‐Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma
por: Ikeda, Sadakatsu, et al.
Publicado: (2018)

Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Challenges
por: Liu, Xiufeng, et al.
Publicado: (2019)

Nivolumab in Advanced Hepatocellular Carcinoma: Safety Profile and Select Treatment‐Related Adverse Events From the CheckMate 040 Study
por: Julien, Karen, et al.
Publicado: (2020)

Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
por: Guler, Ezgi, et al.
Publicado: (2020)

Feasibility and safety of bedside percutaneous biliary drainage in patients with severe cholangitis
por: Gupta, Pankaj, et al.
Publicado: (2020)

Higher frequency of hepatic steatosis at CT among COVID-19-positive patients
por: Medeiros, Augusto Kreling, et al.
Publicado: (2020)

CT of amebic liver abscess: different morphological types with different clinical features
por: Priyadarshi, Rajeev Nayan, et al.
Publicado: (2021)

The natural course of giant paraesophageal hernia and long-term outcomes following conservative management
por: Oude Nijhuis, Renske A B, et al.
Publicado: (2020)

Clinical management of patients with drug‐induced liver injury (DILI)
por: Björnsson, Einar S.
Publicado: (2021)

Impact of thyroid disorders on the incidence of non‐alcoholic fatty liver disease in Germany
por: Labenz, Christian, et al.
Publicado: (2021)

Neoadjuvant Treatment with Angiogenesis‐Inhibitor Dovitinib Prior to Local Therapy in Hepatocellular Carcinoma: A Phase II Study
por: Woei‐A‐Jin, F.J. Sherida H., et al.
Publicado: (2021)

Integrated prognostication of intrahepatic cholangiocarcinoma by contrast-enhanced computed tomography: the adjunct yield of radiomics
por: Silva, Mario, et al.
Publicado: (2021)

Prospective assessment of diagnostic efficacy and safety of Sonazoid(TM) and SonoVue(®) ultrasound contrast agents in patients with focal liver lesions
por: Lv, Ke, et al.
Publicado: (2021)

Referral care paths for non‐alcoholic fatty liver disease—Gearing up for an ever more prevalent and severe liver disease
por: van Dijk, Anne‐Marieke, et al.
Publicado: (2021)

High liver stiffness values by transient elastography related to metabolic syndrome and harmful alcohol use in a large Spanish cohort
por: Llop, Elba, et al.
Publicado: (2021)

Real-time virtual sonography-assisted radiofrequency ablation in liver tumors with conspicuous or inconspicuous images or peritumoral landmarks under ultrasonography
por: Huang, Hsin-Chih, et al.
Publicado: (2021)

Portosystemic shunt surgery in the era of TIPS: imaging-based planning of the surgical approach
por: Fehrenbach, Uli, et al.
Publicado: (2020)

CT angiography of abdomen and pelvis in critically ill COVID-19 patients: imaging findings and correlation with the CT chest score
por: Vadvala, Harshna V., et al.
Publicado: (2021)

Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents
por: Thrane, Karl Julius, et al.
Publicado: (2021)

Screening of radiotracer for diagnosis of colorectal cancer liver metastasis based on MACC1-SPON2
por: Jiang, Hao, et al.
Publicado: (2021)

Epidemiology of pyogenic liver abscesses in Germany: Analysis of incidence, risk factors and mortality rate based on routine data from statutory health insurance
por: Zimmermann, Lisa, et al.
Publicado: (2021)

Reproducibility of liver R2* quantification for liver iron quantification from cardiac R2* acquisitions
por: Muehler, M. R., et al.
Publicado: (2021)

Repeatability and reproducibility of deep-learning-based liver volume and Couinaud segment volume measurement tool
por: Mojtahed, Amirkasra, et al.
Publicado: (2021)

Prevalence and clinical significance of clinically evident portal hypertension in patients with hepatocellular carcinoma undergoing transarterial chemoembolization
por: Müller, Lukas, et al.
Publicado: (2021)

Clinical management of chronic hepatitis B: A concise overview
por: Furquim d’Almeida, Arno, et al.
Publicado: (2021)

Portal hypertension and hepatocellular carcinoma: Navigating uncharted waters
por: Sidali, Sabrina, et al.
Publicado: (2022)

A new proposal for secondary surveillance following potentially curative therapy of HCC: alternating MRI and CEUS
por: Bansal, Sanjay, et al.
Publicado: (2021)

Predictors of biliary intervention in patients hospitalized for COVID-19
por: Chen, Christine, et al.
Publicado: (2022)

Risk stratification tools for branch‐duct intraductal papillary mucinous neoplasms of the pancreas
por: Balduzzi, Alberto, et al.
Publicado: (2022)

Risk of infections and their role on subsequent mortality in biopsy‐proven alcohol‐related liver disease
por: Hagström, Hannes, et al.
Publicado: (2022)

Risk of hepato‐pancreato‐biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population‐based cohort study
por: Yu, Jingru, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_anung7tul88vc4cihtvhb6hfqd