Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure

Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that covalently attach to the catalytic Ser203 residue. Reactivatio...

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Detalles Bibliográficos
Autores principales: Gerlits, Oksana, Blakeley, Matthew P., Keen, David A., Radić, Zoran, Kovalevsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435639/
https://www.ncbi.nlm.nih.gov/pubmed/34541552
http://dx.doi.org/10.1016/j.crstbi.2021.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435639/
https://www.ncbi.nlm.nih.gov/pubmed/34541552
http://dx.doi.org/10.1016/j.crstbi.2021.08.003

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