Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing

Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific transcripts in the thymus, which is essential for efficient removal of dangerou...

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Detalles Bibliográficos
Autores principales: Berger, Amund Holte, Bratland, Eirik, Sjøgren, Thea, Heimli, Marte, Tyssedal, Torgeir, Bruserud, Øyvind, Johansson, Stefan, Husebye, Eystein Sverre, Oftedal, Bergithe Eikeland, Wolff, Anette Susanne Bøe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435668/
https://www.ncbi.nlm.nih.gov/pubmed/34526996
http://dx.doi.org/10.3389/fimmu.2021.722860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435668/
https://www.ncbi.nlm.nih.gov/pubmed/34526996
http://dx.doi.org/10.3389/fimmu.2021.722860

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