Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice

An inherited deficiency of arylsulfatase A (ASA) causes the lysosomal storage disease metachromatic leukodystrophy (MLD) characterized by massive intralysosomal storage of the acidic glycosphingolipid sulfatide and progressive demyelination. Lyso-sulfatide, which differs from sulfatide by the lack o...

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Detalles Bibliográficos
Autores principales: Yaghootfam, Claudia, Gehrig, Bernd, Sylvester, Marc, Gieselmann, Volkmar, Matzner, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435702/
https://www.ncbi.nlm.nih.gov/pubmed/34375644
http://dx.doi.org/10.1016/j.jbc.2021.101064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435702/
https://www.ncbi.nlm.nih.gov/pubmed/34375644
http://dx.doi.org/10.1016/j.jbc.2021.101064

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