A Single L/D-Substitution at Q4 of the mInsA(2-10) Epitope Prevents Type 1 Diabetes in Humanized NOD Mice

Autoreactive CD8(+) T cells play an indispensable key role in the destruction of pancreatic islet β-cells and the initiation of type 1 diabetes (T1D). Insulin is an essential β-cell autoantigen in T1D. An HLA-A*0201-restricted epitope of insulin A chain (mInsA(2-10)) is an immunodominant ligand for...

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Detalles Bibliográficos
Autores principales: Zhang, Mengjun, Wang, Yuanqiang, Li, Xiangqian, Meng, Gang, Chen, Xiaoling, Wang, Lina, Lin, Zhihua, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435724/
https://www.ncbi.nlm.nih.gov/pubmed/34526989
http://dx.doi.org/10.3389/fimmu.2021.713276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435724/
https://www.ncbi.nlm.nih.gov/pubmed/34526989
http://dx.doi.org/10.3389/fimmu.2021.713276

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