Optogenetic Stimulation Using Anion Channelrhodopsin (GtACR1) Facilitates Termination of Reentrant Arrhythmias With Low Light Energy Requirements: A Computational Study

Optogenetic defibrillation of hearts expressing light-sensitive cation channels (e.g., ChR2) has been proposed as an alternative to conventional electrotherapy. Past modeling work has shown that ChR2 stimulation can depolarize enough myocardium to interrupt arrhythmia, but its efficacy is limited by...

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Detalles Bibliográficos
Autores principales: Ochs, Alexander R., Karathanos, Thomas V., Trayanova, Natalia A., Boyle, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435849/
https://www.ncbi.nlm.nih.gov/pubmed/34526912
http://dx.doi.org/10.3389/fphys.2021.718622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435849/
https://www.ncbi.nlm.nih.gov/pubmed/34526912
http://dx.doi.org/10.3389/fphys.2021.718622

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