Mechanistic analysis and significance of sphingomyelinase‐mediated decreases in transepithelial CFTR currents in nHBEs

Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) causes cystic fibrosis (CF). In the lungs, this manifests as immune cell infiltration and bacterial infections, leading to tissue destruction. Previous work has determined that acute bacterial sphingomyelinase (SMase)...

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Detalles Bibliográficos
Autores principales: Cottrill, Kirsten A., Giacalone, Vincent D., Margaroli, Camilla, Bridges, Robert J., Koval, Michael, Tirouvanziam, Rabindra, McCarty, Nael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436056/
https://www.ncbi.nlm.nih.gov/pubmed/34514718
http://dx.doi.org/10.14814/phy2.15023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436056/
https://www.ncbi.nlm.nih.gov/pubmed/34514718
http://dx.doi.org/10.14814/phy2.15023

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