Cargando…

Mechanistic analysis and significance of sphingomyelinase‐mediated decreases in transepithelial CFTR currents in nHBEs

Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) causes cystic fibrosis (CF). In the lungs, this manifests as immune cell infiltration and bacterial infections, leading to tissue destruction. Previous work has determined that acute bacterial sphingomyelinase (SMase)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cottrill, Kirsten A., Giacalone, Vincent D., Margaroli, Camilla, Bridges, Robert J., Koval, Michael, Tirouvanziam, Rabindra, McCarty, Nael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436056/ https://www.ncbi.nlm.nih.gov/pubmed/34514718 http://dx.doi.org/10.14814/phy2.15023

Ejemplares similares

Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance
por: Cottrill, Kirsten A., et al.
Publicado: (2021)

The bidirectional relationship between CFTR and lipids
por: Cottrill, Kirsten A., et al.
Publicado: (2020)

Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)
por: Stauffer, B. B., et al.
Publicado: (2017)

Tweaking the catalytic efficiency of the CFTR ion channel
por: McCarty, Nael A.
Publicado: (2023)

Mass production of human airway-like neutrophils via transmigration in an organotypic model of human airways
por: Dobosh, Brian, et al.
Publicado: (2021)

Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease
por: Giacalone, Vincent D., et al.
Publicado: (2020)

Immunomodulation in Cystic Fibrosis: Why and How?
por: Giacalone, Vincent D., et al.
Publicado: (2020)

Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease
por: Margaroli, Camilla, et al.
Publicado: (2016)

The molecular evolution of function in the CFTR chloride channel
por: Infield, Daniel T., et al.
Publicado: (2021)

Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Channel Activity
por: Cui, Guiying, et al.
Publicado: (2021)

Modeling the Conformational Changes Underlying Channel Opening in CFTR
por: Rahman, Kazi S., et al.
Publicado: (2013)

Functional and Transcriptional Adaptations of Blood Monocytes Recruited to the Cystic Fibrosis Airway Microenvironment In Vitro
por: Ford, Bijean D., et al.
Publicado: (2021)

Relating the Disease Mutation Spectrum to the Evolution of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
por: Rishishwar, Lavanya, et al.
Publicado: (2012)

Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR
por: Cui, Guiying, et al.
Publicado: (2014)

Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections
por: Grunwell, Jocelyn R., et al.
Publicado: (2019)

Cftr: Covalent and Noncovalent Modification Suggests a Role for Fixed Charges in Anion Conduction
por: Smith, Stephen S., et al.
Publicado: (2001)

Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm
por: Moffett, Alexander S., et al.
Publicado: (2022)

VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level
por: Cui, Guiying, et al.
Publicado: (2019)

Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells
por: Froux, Lionel, et al.
Publicado: (2019)

Mechanistic Insight into Control of CFTR by AMPK
por: Kongsuphol, Patthara, et al.
Publicado: (2009)

Sinupret Activates CFTR and TMEM16A-Dependent Transepithelial Chloride Transport and Improves Indicators of Mucociliary Clearance
por: Zhang, Shaoyan, et al.
Publicado: (2014)

Breathe—Your immune system is counting on it
por: McCarty, Nael A.
Publicado: (2021)

Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils
por: Margaroli, Camilla, et al.
Publicado: (2021)

Pulmonary exacerbations in early cystic fibrosis lung disease are marked by strong modulation of CD3 and PD-1 on luminal T cells
por: Giacalone, Vincent D., et al.
Publicado: (2023)

Effect of Sphingomyelinase-Treated LDLs on HUVECs
por: Giuliani, Angelica, et al.
Publicado: (2023)

Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysis
por: C, Lavanya, et al.
Publicado: (2022)

Functional Consequences of GPCR Heterodimerization: GPCRs as Allosteric Modulators
por: Haack, Karla K.V., et al.
Publicado: (2011)

Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential
por: Adams, Emily D. M., et al.
Publicado: (2010)

The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients
por: Margaroli, Camilla, et al.
Publicado: (2020)

Sphingomyelinases and Liver Diseases
por: Insausti-Urkia, Naroa, et al.
Publicado: (2020)

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls
por: Lea, Simon R, et al.
Publicado: (2016)

Transepithelial Photorefractive Keratectomy with Crosslinking for Keratoconus
por: Mukherjee, Achyut N, et al.
Publicado: (2013)

Formaldehyde impairs transepithelial sodium transport
por: Cui, Yong, et al.
Publicado: (2016)

Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection
por: Laucirica, Daniel R, et al.
Publicado: (2022)

Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages
por: Zughaier, Susu M., et al.
Publicado: (2014)

Disseminated Coccidioidomycosis Among Children in Central California: A Retrospective Review
por: Naeem, Fouzia, et al.
Publicado: (2017)

Acid sphingomyelinase deals the seal
por: Short, Ben
Publicado: (2010)

Findings from a feasibility study of estradiol for hypogonadal women with cystic fibrosis-related bone disease
por: Wu, Malinda, et al.
Publicado: (2021)

Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma
por: Wątek, Marzena, et al.
Publicado: (2019)

Epithelial permeability and the transepithelial migration of human neutrophils
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_pnc46s0p7a3b7v6n17jg18f6mu