A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrophiles adduct within the catalytic domain, inhibiti...

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Detalles Bibliográficos
Autores principales: Charles, Rebecca L., Abis, Giancarlo, Fernandez, Beatriz F., Guttzeit, Sebastian, Buccafusca, Roberto, Conte, Maria R., Eaton, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436062/
https://www.ncbi.nlm.nih.gov/pubmed/34509915
http://dx.doi.org/10.1016/j.redox.2021.102107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436062/
https://www.ncbi.nlm.nih.gov/pubmed/34509915
http://dx.doi.org/10.1016/j.redox.2021.102107

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