Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives

The dysregulation of Notch signaling is found in many cancers and is closely related to cancer progression. As an important Notch receptor, abnormal Notch4 expression affects several tumor-cell behaviors, including stemness, the epithelial–mesenchymal transition, radio/chemoresistance and angiogenes...

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Detalles Bibliográficos
Autores principales: Xiu, Mengxi, Zeng, Xiaohong, Shan, Renfeng, Wen, Wu, Li, Jianfeng, Wan, Renhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436177/
https://www.ncbi.nlm.nih.gov/pubmed/34526819
http://dx.doi.org/10.2147/CMAR.S315511
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author Xiu, Mengxi
Zeng, Xiaohong
Shan, Renfeng
Wen, Wu
Li, Jianfeng
Wan, Renhua
author_facet Xiu, Mengxi
Zeng, Xiaohong
Shan, Renfeng
Wen, Wu
Li, Jianfeng
Wan, Renhua
author_sort Xiu, Mengxi
collection PubMed
description The dysregulation of Notch signaling is found in many cancers and is closely related to cancer progression. As an important Notch receptor, abnormal Notch4 expression affects several tumor-cell behaviors, including stemness, the epithelial–mesenchymal transition, radio/chemoresistance and angiogenesis. In order to inhibit the oncogenic effects of Notch4 activation, several methods for targeting Notch4 signaling have been proposed. In this review, we summarize the known molecular mechanisms through which Notch4 affects cancer progression. Finally, we discuss potential Notch4-targeting therapeutic strategies as a reference for future research.
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spelling pubmed-84361772021-09-14 Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives Xiu, Mengxi Zeng, Xiaohong Shan, Renfeng Wen, Wu Li, Jianfeng Wan, Renhua Cancer Manag Res Review The dysregulation of Notch signaling is found in many cancers and is closely related to cancer progression. As an important Notch receptor, abnormal Notch4 expression affects several tumor-cell behaviors, including stemness, the epithelial–mesenchymal transition, radio/chemoresistance and angiogenesis. In order to inhibit the oncogenic effects of Notch4 activation, several methods for targeting Notch4 signaling have been proposed. In this review, we summarize the known molecular mechanisms through which Notch4 affects cancer progression. Finally, we discuss potential Notch4-targeting therapeutic strategies as a reference for future research. Dove 2021-09-08 /pmc/articles/PMC8436177/ /pubmed/34526819 http://dx.doi.org/10.2147/CMAR.S315511 Text en © 2021 Xiu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xiu, Mengxi
Zeng, Xiaohong
Shan, Renfeng
Wen, Wu
Li, Jianfeng
Wan, Renhua
Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title_full Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title_fullStr Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title_full_unstemmed Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title_short Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
title_sort targeting notch4 in cancer: molecular mechanisms and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436177/
https://www.ncbi.nlm.nih.gov/pubmed/34526819
http://dx.doi.org/10.2147/CMAR.S315511
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