Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases

[Image: see text] An undecamer oligonucleotide probe based on a pair of deoxythymidines flanked by several modified nucleotides is a specific and highly efficient biosensor for micrococcal nuclease (MNase), an endonuclease produced by Staphylococcus aureus. Herein, the interaction mode and cleavage...

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Detalles Bibliográficos
Autores principales: Jiménez, Tania, Botero, Juliana, Otaegui, Dorleta, Calvo, Javier, Hernandez, Frank J., San Sebastian, Eider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436206/
https://www.ncbi.nlm.nih.gov/pubmed/34460263
http://dx.doi.org/10.1021/acs.jmedchem.1c00884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436206/
https://www.ncbi.nlm.nih.gov/pubmed/34460263
http://dx.doi.org/10.1021/acs.jmedchem.1c00884

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