Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics

[Image: see text] Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (vitamin B3) to generate 1-methylnicotinamide (MNA). NNMT overexpression has been linked to a variety of diseases, most prominently human cancers, indicating its potential as a therapeutic target. The development of sm...

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Detalles Bibliográficos
Autores principales: Gao, Yongzhi, van Haren, Matthijs J., Buijs, Ned, Innocenti, Paolo, Zhang, Yurui, Sartini, Davide, Campagna, Roberto, Emanuelli, Monica, Parsons, Richard B., Jespers, Willem, Gutiérrez-de-Terán, Hugo, van Westen, Gerard J. P., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436214/
https://www.ncbi.nlm.nih.gov/pubmed/34424711
http://dx.doi.org/10.1021/acs.jmedchem.1c01094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436214/
https://www.ncbi.nlm.nih.gov/pubmed/34424711
http://dx.doi.org/10.1021/acs.jmedchem.1c01094

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