Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

[Image: see text] Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR for this chemotype, with improve...

Descripción completa

Detalles Bibliográficos
Autores principales: McGillan, Paul, Berry, Neil G., Nixon, Gemma L., Leung, Suet C., Webborn, Peter J. H., Wenlock, Mark C., Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H., Cook, Darren A., Johnston, Kelly L., Ford, Louise, Ward, Stephen A., Taylor, Mark J., Hong, W. David, O’Neill, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436242/
https://www.ncbi.nlm.nih.gov/pubmed/34527179
http://dx.doi.org/10.1021/acsmedchemlett.1c00216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436242/
https://www.ncbi.nlm.nih.gov/pubmed/34527179
http://dx.doi.org/10.1021/acsmedchemlett.1c00216

Ejemplares similares