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Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

[Image: see text] Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR for this chemotype, with improve...

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Detalles Bibliográficos
Autores principales:	McGillan, Paul, Berry, Neil G., Nixon, Gemma L., Leung, Suet C., Webborn, Peter J. H., Wenlock, Mark C., Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H., Cook, Darren A., Johnston, Kelly L., Ford, Louise, Ward, Stephen A., Taylor, Mark J., Hong, W. David, O’Neill, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436242/ https://www.ncbi.nlm.nih.gov/pubmed/34527179 http://dx.doi.org/10.1021/acsmedchemlett.1c00216

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