LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression

BACKGROUND: Microglia-mediated neuroinflammation plays an important role in Parkinson’s disease (PD), and it exerts proinflammatory or anti-inflammatory effects depending on the M1/M2 polarization phenotype. Hence, promoting microglia toward the anti-inflammatory M2 phenotype is a potential therapeu...

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Detalles Bibliográficos
Autores principales: Yang, Xiaodong, Zhang, Yi, Chen, Yimeng, He, Xiaoqin, Qian, Yiwei, Xu, Shaoqing, Gao, Chao, Mo, Chengjun, Chen, Shengdi, Xiao, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436538/
https://www.ncbi.nlm.nih.gov/pubmed/34511122
http://dx.doi.org/10.1186/s12974-021-02267-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436538/
https://www.ncbi.nlm.nih.gov/pubmed/34511122
http://dx.doi.org/10.1186/s12974-021-02267-z

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