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LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression

BACKGROUND: Microglia-mediated neuroinflammation plays an important role in Parkinson’s disease (PD), and it exerts proinflammatory or anti-inflammatory effects depending on the M1/M2 polarization phenotype. Hence, promoting microglia toward the anti-inflammatory M2 phenotype is a potential therapeu...

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Detalles Bibliográficos
Autores principales:	Yang, Xiaodong, Zhang, Yi, Chen, Yimeng, He, Xiaoqin, Qian, Yiwei, Xu, Shaoqing, Gao, Chao, Mo, Chengjun, Chen, Shengdi, Xiao, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436538/ https://www.ncbi.nlm.nih.gov/pubmed/34511122 http://dx.doi.org/10.1186/s12974-021-02267-z

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