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Fluorescence lifetime imaging reveals regulation of presynaptic Ca(2+) by glutamate uptake and mGluRs, but not somatic voltage in cortical neurons

ABSTRACT: Brain function relies on vesicular release of neurotransmitters at chemical synapses. The release probability depends on action potential‐evoked presynaptic Ca(2+) entry, but also on the resting Ca(2+) level. Whether these basic aspects of presynaptic calcium homeostasis show any consisten...

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Detalles Bibliográficos
Autores principales: Tyurikova, Olga, Zheng, Kaiyu, Nicholson, Elizabeth, Timofeeva, Yulia, Semyanov, Alexey, Volynski, Kirill E., Rusakov, Dmitri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436763/
https://www.ncbi.nlm.nih.gov/pubmed/32418206
http://dx.doi.org/10.1111/jnc.15094