DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis

Intervertebral disc degeneration (IVDD) is a main cause of low back pain that is associated with extracellular matrix (ECM) degradation and inflammation. This study aims to investigate the role of DNMT3B and its regulatory mechanisms in IVDD. IVDD rat models were constructed followed by transfection...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Zhiqiang, Ma, Yanchao, Di, Tianning, Ma, Bing, Li, Hongwei, An, Jiangdong, Wang, Yonggang, Zhang, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436916/
https://www.ncbi.nlm.nih.gov/pubmed/34428744
http://dx.doi.org/10.18632/aging.203410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436916/
https://www.ncbi.nlm.nih.gov/pubmed/34428744
http://dx.doi.org/10.18632/aging.203410

Ejemplares similares